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Advanced Glycation End Products – Pre Screening solution for Diabetes

At OICO we seek out new projects that maximise positive impact on society. We regularly scour the latest scientific works for ideas. Our intention is to convert scientific advances into affordable usable devices in the shortest possible period of time. Narrowing the gap between science and end user diagnostics.

It is within this context that we stumbled upon Advanced Glycation End Products. I won’t go into the details of AGEs (a quick google read up will do a better job than I could). So I’ll jump straight into what we’ve done with AGEs.

AGEs build up in the intra occular (crystaline) lens of the eye over our lifetimes. People at risk of Diabetes (or even Alzheimers) build up more AGEs than “normal” people.

So when measuring the AGE in the crystaline lens and taking into account a patients age, we can estimate whether the person is at high or low risk of developing Diabetes or Alzheimers. AGEs fluorescence at a certain wavelength. SO actually detecting the AGE levels is quite simple with a photon source at wavelength A, and detectors tuned for wavelength B to pick up the fluorescence intensity. There’s no need for any eye drops or tablets as the activation is purely by the wavelength of light.

This method is actually better than blood testing for early stage Diabetes, as blood sugar levels fluctuate, but AGEs are permanent. In addition the test itself takes only a few seconds, allowing a lightly trained domiciliary medical visitor to pre-screen hundreds of people per day using a single device.

 

Once the patient’s age is entered the device can give a simple answer as to the risk levels of the person’s AGE for Diabetes and potentially Alzheimer’s, before the onset of any symptoms.

 

Our handheld AGE reader will be available for sale within the next few months. We shall be demonstrating them at our future exhibitions. 

Developing our Multi Spectral Imager and Tomography device

At OICO we’ve had many requests from both customers and prospective customers to develop an affordable Optical Coherence Tomography (OCT) machine.

Over the last 6 months we’ve gone through an internal development process and reviewed the current state of the art in the OCT marketplace to get an understanding as to the functionality that vendors are including in their offerings.

We then went back to basics and reviewed the functionality actually utilised by end users.

As always, the solutions from other vendors are overly complex and all vendors follow each other down a narrow developmental path.

Us, being OICO, weren’t interested in simply following down the beaten track… we went back to basics on how to accurately take tomographic slices of the retina.

 

We wanted to get rid of the 19th century era Michelson Interferometer, and eliminate the alignment issues associated with slow scanning of multiple images. We also wanted to get rid of the expense associated with the need for coherent illumination and swept sources.

Multi Spectral Imager and Tomography

So what was the solution we came up with?

We sought out various nanotechnology to reduce the expense of polarisation, and built our own switching illumination sources in house to slash costs. We also fundamentally altered the way the scans are captured and use area scan as opposed to line scan to eliminate the need for complex post processing alignment operations.

In brief,  we eliminated over 90% of the complexity of OCT when building our MSIT. Yes we still need fast fourier transforms. However now we offer our end users easy to use C-scan images in a system that a novice with only brief training can use effectively.

Expect to see our MSIT for sale on our website in the next few months.